Comparison of Hemoglobin Binding, Mutagenicity, and Carcinogenicity of Arylamines and Nitroarenes
N-Oxidation and nitro-reduction which yield N-hydroxyarylamines are metabolic steps that are crucial for the genotoxic and toxic properties of aromatic amines and nitroarenes, respectively.N-Hydroxyarylamines form adducts with DNA, tissue proteins, and blood proteins.Except for nine compounds, it has been shown that after treatment of rats with nit